Raji cd47
Tīmeklis新的cd47单克隆抗体及其应用专利检索，新的cd47单克隆抗体及其应用属于·对白血病有特异性的专利检索，找专利汇即可免费查询专利，·对白血病有特异性的专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 Tīmeklis2024. gada 6. aug. · To evaluate in vivo anti-tumor activity of IBI322, NOD-SCID mice with PD-L1/CD47-expressing Raji tumor were treated with antibodies. The result is shown in Fig. 6a and S4. All other treatment groups, including anti-CD47 monotherapy, anti-PD-L1 monotherapy, and the combo of anti-PD-L1 and anti-CD47, were …
Raji cd47
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Tīmeklis2011. gada 3. nov. · CD47 knockdown Raji cells developed an average 4-fold fewer liver lesions, compared with control, with several mice showing complete absence of … Tīmeklis2024. gada 24. jūn. · CD47 is a widely expressed cell-surface protein that regulates phagocytosis mediated by cells of the innate immune system, such as macrophages and dendritic cells. CD47 serves as the ligand for a receptor on these innate immune cells, signal regulatory protein (SIRP)-α, which in turn inhibits phagocytosis. Several …
Tīmeklis2010. gada 3. sept. · Using Raji, SUDHL4, and NHL17 cells, which express varying levels of both CD47 and CD20 (Figure S2 K), anti-CD47 antibody synergized with rituximab or anti-human CD20 (mouse IgG2a) antibody, as indicated by combination indices less than 1 (Figure 2 C). In a second approach, in vitro phagocytosis assays … HEK-293F, CHO-S, Raji, SK-OV-3 and Jurkat E6.1 cells were obtained from the American Type Culture Collection (ATCC). HEK-293F cells and CHO-S cells were cultured in FreeStyle™ 293 or FreeStyle™ CHO expression medium (Invitrogen, Carlsbad, CA, USA) respectively, supplemented with 1% … Skatīt vairāk hCD47 ectodomain (ECD) (20–136) or hSIRPα (ECD) (31–373) fused to human Fc fragment were amplified by PCR and cloned into pFUSE vector (Invitrogen). hCD47 (ECD)-Fc and hSIRPα (ECD)-Fc were expressed … Skatīt vairāk For preparation of positive control antibodies including B6H12, Hu5F9-G4 or Rituximab (CD20 mAb), the DNA sequences of their … Skatīt vairāk A young healthy male Bactrian camel was firstly immunized with hCD47(ECD)-Fc mixed with an equal volume of Freund’s complete adjuvant … Skatīt vairāk Nbs specific binding to human CD47 were screened through phage display and Periplasmic Extract ELISA (PE-ELISA), according to previously described procedure [21, … Skatīt vairāk
Tīmeklis2024. gada 13. nov. · Like other anti-CD47 antibodies, TJC4 blocks the interaction of CD47 and SIRPa, leading to the enhanced macrophage phagocytosis of various … Tīmeklis2024. gada 23. nov. · Although anti-CD47 therapies have demonstrated promising clinical activities, the expression of CD47 on many different normal human cell types, including red blood cells (RBCs), serves as a large antigen sink for anti-CD47 antibodies. ... In both the disseminated and subcutaneous CD47-positive Raji tumor …
Tīmeklis2011. gada 3. nov. · CD47 expression was required for Raji cell dissemination to the liver in mouse xenotransplants. Targeting of CD47 with a blocking antibody inhibited …
Tīmeklis2024. gada 6. marts · We further assessed the in vivo tumor suppression efficacy of the CD47-targeting antibody, h4C1, in a mouse model. We subcutaneously engrafted … teikit sabadellTīmeklisB, The number of CD19, CD20 and CD47 per cell on Raji cells or the CD47-silenced clone Raji cells was quantified using the Qifikit®. Histograms represent the mean ± … emoji narizonteikuma veidiTīmeklis抗cd47单克隆抗体及其应用专利检索，抗cd47单克隆抗体及其应用属于·对白血病有特异性的专利检索，找专利汇即可免费查询专利，·对白血病有特异性的专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 teikoreaTīmeklis2024. gada 9. maijs · The Raji CD47 silenced cell line was derived from original wild-type (wt) Raji cells transfected with short hairpin (sh) RNA, subcloned, screened by flow cytometry and finally selected as the most silenced stable clone by quantification of CD47 receptors using QIFIKIT® (DAKO). Cells were cultured at 37°C and 5% CO2. teikoku tsushin kogyo co. ltdTīmeklis在扩散性和皮下CD47阳性的Raji肿瘤模型中，IgG4同型的ADG153 SAFEbody显示出与Hu5F9相似的抗肿瘤活性。 安全性上，在犬猴的探索性毒理学研究中， ADG153 SAFEbody在红细胞、血红蛋白和血细胞比值方面的降幅明显低于Hu5F9。 emoji name symbolsTīmeklis2024. gada 20. okt. · Overexpression of other molecules interacting with NK inhibitory receptors 39,40 or CD47, ... 7.5 μg of gRNA in total were used. 4 × 10 5 Raji cells were transfected with the Cas9/gRNA ... emoji nao aparece