WebBackground: p21/CIP1/CDKN1A. p21/CIP1 is a Cyclin/Cyclin-dependent kinase (Cdk) inhibitor that blocks progression from G1 to S phase in the cell cycle. The expression of p21, a transcriptional target of p53, increases in cells where p53 is stabilized due to exposure to genotoxic agents. WebApr 4, 2024 · CDKN1A (p21) was identified as a functional target of miR-33b-3p, a critical regulator of G1/S checkpoint, which potentially mediated the protection effects of miR …
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WebOct 14, 2016 · The p21 protein (also known as p21 CDKN1A and p21 Cip1/Waf1), is a member of the family of cyclin-dependent kinase (CDK) inhibitors (CKIs) which has long been known for its ability to consolidate the G1 and G2 arrest after DNA damage caused by genotoxic agents, such as γ irradiation (γ IR) (Brugarolas et al., 1995; Bunz et al., 1998; … WebNov 8, 2024 · We identify CDKN1A (p21) as a transcriptional repressor of the phagocytosis inhibitory receptor SIRPα and consequently as a therapeutic target for overcoming the CD47-dependent phagocytosis...
WebNov 30, 2024 · p21 Waf1/Cip1 Antibody (F-5) is an IgG 2b κ mouse monoclonal p21 Waf1/Cip1 antibody (also designated CIP1 antibody, WAF1 antibody, CDKN1A antibody or p21 antibody) suitable for the detection of the p21 Waf1/Cip1 protein of mouse, rat and human origin by WB, IP, IF, IHC (P) and FCM. p21 Waf1/Cip1 Antibody (F-5) is available as … WebJan 28, 2024 · p21 Waf1/Cip1/CDKN1A Antibody (187) is an IgG 1 κ mouse monoclonal p21 Waf1/Cip1 antibody that detects p21 Waf1/Cip1 of mouse, rat and human origin by WB, IP, IF, IHC (P) and ELISA. p21 Waf1/Cip1/CDKN1A Antibody (187) is available as the non-conjugated anti-p21 Waf1/Cip1 antibody form, as well as multiple conjugated forms of …
WebOct 2, 2024 · CDKN1A and CDKN2B were significantly downregulated in HCC cells after SNHG1 overexpression while CDKN1A and CDKN2B were obviously upregulated in HCC cells after EZH2 knockdown (Fig. 6b–d). CDK inhibition p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4/6 complexes, and thus functions as a regulator of cell cycle progression at G1 and S phase. The binding of p21 to CDK complexes occurs … See more p21 (alternatively p21 ), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily … See more p53 dependent response Studies of p53 dependent cell cycle arrest in response to DNA damage identified p21 as the primary mediator of downstream cell cycle arrest. Notably, El-Deiry et al. identified a protein p21 (WAF1) which was present in cells … See more • Marone M, Bonanno G, Rutella S, Leone G, Scambia G, Pierelli L (2002). "Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21". Leuk. Lymphoma. 43 (1): 51–7. doi: • Fang JY, Lu YY (2002). See more Cytoplasmic p21 expression can be significantly correlated with lymph node metastasis, distant metastases, advanced TNM stage … See more • Nrf2 • BCCIP, • CIZ1, • CUL4A, • CCNE1, See more • Cyclin-Dependent+Kinase+Inhibitor+p21 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Drosophila dacapo - The Interactive Fly • CDKN1A human gene location in the UCSC Genome Browser. See more
WebWestern blot - CDKN1A/p21CIP1 Rabbit pAb (A1483) Western blot analysis of MCF7, using CDKN1A/p21CIP1 antibody (A1483) at 1:900 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020).
WebMar 31, 2024 · The p21-encoding gene CDKN1A is a prominent p53 target (Fig. 1 ). p53 binds to elements in the p21/ CDNKN1A promoter and activates its transcription [ 39 ]. … russian revolution primary sourcesWebTo investigate the effect of a novel p21-modulating protein WISp39 on proliferation, apoptosis and cell cycle of leukemia cells, the plasmid pLenti6/V5-WISp39 was constructed and transfected into the human myelocytic leukemia cell line-U937 cells. ... CDKN1A protein, human Cyclin-Dependent Kinase Inhibitor p21 FKBPL protein, human RNA ... scheduled roadworksWebApr 6, 2024 · Elevated expression of the cyclin-dependent kinase inhibitor 1a (CDKN1A; known alternatively as p21 cip1/waf1) induces senescence, a form of cell cycle arrest, and … scheduled rocket launches 2021WebGregory A. Komenda, MD, is a board-certified orthopedic surgeon whose primary focus is on sports medicine and injuries of the shoulder and knee. He enjoys working with patients … russian revolution red vs whiteWebApr 6, 2024 · This study examined the role of cyclin-dependent kinase inhibitor 1a (CDK1A, p21) in response to exogenous stressors during mouse preimplantation embryo development. CDKN1A knockdown (KD) one-cell zygotes were exposed to 39 °C heat stress (HS) for 4 days or irradiated by 1 (1-Gy) or 3 (3-Gy) Gy X-rays, and their developmental … scheduled road works near meWebCDKN1A (CAP20, CDKN1, CIP1, P21, p21CIP1, p21Cip1/Waf1, SDI1, WAF1) Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl. A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the ... russian revolution posters graphicWebMay 1, 2003 · Two genes of interest are p21cip1 (CDKN1A) and p27kip1 (CDKN1B), members of the cip/kip family of cdk 3 inhibitors. The cip/kip family members inhibit phosphorylation of the retinoblastoma protein (Rb) through binding to cyclin-cdk complexes: cyclin E-cdk2; cyclin A-cdk2; and cyclin D-cdk4 (5, 6, 7). russian revolution red army