WebThe BLM gene product, BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks by the homologous recombination (HR) pathway. During HR, BLM has both pro- and anti-recombinogenic activities, either of which may contribute to maintenance of genomic integrity. WebSgs1, also known as slow growth suppressor 1, is a DNA helicase protein found in Saccharomyces cerevisiae.It is a homolog of the bacterial RecQ helicase. Like the other members of the RecQ helicase family, Sgs1 is important for DNA repair.In particular, Sgs1 collaborates with other proteins to repair double-strand breaks during homologous …

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WebBloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cells from persons with Bloom syndrome exhibit striking genomic instability characterized by ... The Sgs1(BLM) helicase appears to be a central regulator of most of the recombination events that occur during S. cerevisiae meiosis. During normal meiosis Sgs1(BLM) is responsible for directing recombination towards the alternate formation of either early NCOs or Holliday junction joint … See more Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome. The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA See more Recombination during meiosis is often initiated by a DNA double-strand break (DSB). During recombination, sections of DNA at the 5' ends of the break are cut away in a process … See more • Woo LL, Onel K, Ellis NA (2007). "The broken genome: genetic and pharmacologic approaches to breaking DNA". Ann. Med. 39 (3): 208–18. doi:10.1080/08035250601167136. PMID 17457718. S2CID 30395226. • McDaniel LD, Schultz RA (1992). See more Bloom syndrome protein has been shown to interact with: • ATM, • CHAF1A, • CHEK1, See more • GeneReviews/NCBI/NIH/UW entry on Bloom Syndrome • Human BLM genome location and BLM gene details page in the UCSC Genome Browser. See more how to enter a mrbeast gaming challenge

BLM BLM RecQ like helicase [Homo sapiens (human)] - Gene - NCBI

WebRecQ helicases, including yeast Sgs1 and human BLM, have been implicated in both replication and recombination and protect genome integrity by preventing unscheduled mitotic recombination events. We have studied the RecQ helicase-mediated mechanisms controlling genome stability by analyzing replication forks encountering a damaged … WebNov 27, 2013 · Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism … WebTaken together, these findings suggest that BLM-deficient cells are in a perpetual state of oxidative stress and that the BLM helicase is important for maintaining cellular redox homeostasis.... how to enter a mrbeast challenge